加州大学圣地亚哥分校招聘两名博士后

药明康德/报道

Job description

Postdoctoral Positions

Membrane remodeling in muscle function and myopathy 

Two NIH-funded postdoctoral positions are immediately available to study cellular and molecular mechanisms of muscle T-tubule membrane organization and remodeling, with an emphasis on the underlying membrane trafficking and its regulation involved in muscle function and models of human myopathy.

Applicants must have a recent Ph.D. (or plans to complete in near future) in cell-developmental biology or related field. Ideal candidates are highly motivated with expertise in at least several of these areas: membrane biology/trafficking, muscle biology, microscopy imaging and image analysis, tissue dissections, Drosophila genetics, molecular biology and/or biochemistry. Of particular interest are applicants familiar with or strongly interested in pursuing animal studies that combine modern genetic modifications with advanced live cell microscopy imaging techniques to understand the cell biological basis of tissue function.

The research goal is to define mechanisms of regulated T-tubule membrane remodeling in normal Drosophila muscle function and models of human myopathy. Current projects build on our published and unpublished studies and novel genetic screen results in Drosophila muscles that address factors involved in shaping and remodeling T-tubule membranes critical for muscle function and relevance to human disease (see Ribeiro et al. 2011 PLoS Genetics; Fujita et al. 2017 eLife). Specific projects explore novel endocytic and autophagic mechanisms involved in regulated disassembly and reassembly of T-tubule membranes during developmental and adult muscle remodeling programs.

Muscle projects parallel additional ongoing research in the lab on the regulation of phosphoinositide functions, endolysosomal trafficking and autophagy in other fly tissues and human cells. Postdoctoral candidates broadly interested in these areas are also encouraged to apply.

Successful candidates will join a dynamic research environment within the UCSD Division of Biological Sciences, with access to the many additional scientific benefits and life/career opportunities in the broader San Diego research community.

Interested candidates should email Dr. Amy Kiger (akiger@ucsd.edu). Applicants should email cover letter, CV, summary of previous research experience and recent publications, and upon request, three letters of references.

UC San Diego is an equal opportunity/affirmative action employer with a strong institutional commitment to the achievement of diversity.

Dr. Amy Kiger

Associate Professor, Division of Biological Sciences

University of California, San Diego

Natural Science Building Room 6109

9500 Gilman Drive MC 0380

La Jolla, CA 92093-0380

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